At SyVento BioTech, we specialize in encapsulating your ideas and transforming them into cutting-edge pharmaceutical products using our advanced lipid-based drug delivery systems and LNP technology.


Lipid-based delivery systems can be carriers for a wide range of drug substances, including nucleic acids, small molecules (both hydrophilic and hydrophobic), peptides, and proteins.

The surface of liposomes and lipid nanoparticles can be modified with various molecules to facilitate targeting and enhance the therapeutic effect of the encapsulated drug.By encapsulating drugs, liposomes and LNPs can also facilitate targeted drug delivery to specific cells or tissues, enhancing their efficacy while minimizing adverse effects. Therefore, incorporating liposomes and LNPs into drug delivery systems is a promising strategy for optimizing drug therapy. They can also enable targeted drug delivery by attachment of antibodies (or their fragments), aptamers, peptides or any other ligands to their Surface that selectively bind to receptors on specific cells or tissues.

Liposomes and lipid nanoparticles are versatile drug delivery systems that offer several advantages over conventional drug formulations.
Liposomes are spherical vesicles composed of a lipid bilayer that can encapsulate both hydrophilic and hydrophobic drugs. Lipid nanoparticles, including solid lipid nanoparticles and nanostructured lipid carriers, are solid or semisolid particles composed of a lipid matrix that can also encapsulate a wide range of drugs. Liposomes and lipid nanoparticles (LNPs) play a crucial role in improving the pharmacokinetic and pharmacodynamic properties of drugs. These delivery systems protect drugs from degradation, enhance their solubility, and increase their bioavailability.

LNP


The history of lipid nanoparticle (LNP) research and development is characterized by continuous innovation and the pursuit of more effective drug delivery systems. Since the development of liposomes in 1965, researchers have been working on refining and expanding the applications of these lipid-based delivery systems. The 1978 development of liposome-mRNA formulations marked a pivotal moment in the intersection of RNA-based medicine and lipid-based delivery systems.

Over the years, various LNPs encapsulating different drugs have been approved by the FDA, and the use of LNP delivery systems for mRNA vaccines in 2020 showcased their potential to revolutionize medicine. SyVento BioTech builds on this legacy, actively shaping the landscape by developing cutting-edge lipid-based delivery systems that enable the safe and effective delivery of RNA-based therapeutics.

We offer the development of encapsulated drugs for all kinds of pharmaceutically active ingredients based on various lipid-based formulations such as:


  • Liposomes
  • Lipid nanoparticles (LNP) for gene therapies (both DNA & RNA)
  • Solid Lipid Nanoparticles (SLN)
  • Nanostructured lipid carriers (NLC)
  • Nanoemulsions
  • Self-emulsifying drug delivery system (SEDDS)

The developed formations are tested in accordance with the QbD (Quality by Design) and ICH guidelines.

As a biotechnology company, we offer contract development and production services that leverage our deep expertise and state-of-the-art facility.

Our team of experienced scientists and engineers work closely with our clients to develop customized solutions that meet their unique needs.

Partnering with SyVento BioTech gives you access to the latest industry developments and regulatory compliance, all while delivering innovative platform solutions that exceed your expectations.

Encapsulate your ideas with SyVento BioTech

and unlock the potential of lipid-based nanocarrier technology.

Advantages of lipid-based drug delivery systems


Increase in efficacy and therapeutic index

Act as Scaffold for additional agents

Possibility of several routes of administration (both inhalator and intravenous)

Increases half life of drug

Biodegradable, bio-compatible & non-immunogenic

Can be made into variety of sizes

Reduced dosage

Reduces systemic toxicity of drug
(eg. Taxol, Amphotericin B)

Protect encapsulated drug from metabolic digestion

Can be targeted to specific tissues or cells

Can carry both lipid & water soluble drugs

Improved pharmacokinetic perfomance

Can be used as sustained drug release

Amphiphilic

It helps in reducing the exposure of sensitive tissues to toxic drugs

(unmodified Liposomes
gather in specific
tissues like
reticuloendothelial system)

Yadav D, Sandeep K, Pandey D, Dutta RK (2017) Liposomes for Drug Delivery. J Biotechnol Biomater 7: 276. DOI: 10.4172/2155-952X.1000276

Explore the benefits of our delivery platform:


Our team at SyVento BioTech possesses extensive qualifications and experience, enabling us to expertly develop lipid-based delivery systems, specifically focusing on LNP technology, which fosters essential outcomes like improved efficacy and enhanced support for diverse applications. Our LNP delivery systems:

  • help overcome the challenges of delivering fragile and easily degraded RNA molecules
  • improve the efficacy of mRNA based drugs are designed and optimized to achieve specific drug delivery goals
  • their modularity allows for precise control over the size surface charge, and composition

Lipid-based formulations are at the forefront of innovation in drug delivery systems. SyVento Biotech's platform solutions offer exciting possibilities for the future of drug products, with continued research and development in this area leading to new and innovative drug therapies that are more effective, safer, and better tolerated by patients.


A Comprehensive History of Lipid Nanoparticles for Drug Delivery Systems
Exploring the Potential of Lipid Nanoparticle Technology for Targeted Drug Delivery
Enhancing mRNA Vaccine Stability and Efficacy through Lipid Nanoparticle Optimization